FB体育

主要研究方向

1. DNA 结构识别与调控

2.  分子逻辑电路的设计与应用

3.  细菌的种属及耐药性分析

主要工作业绩

主要从事DNA的结构识别、调控与自组装，及其在生物靶标检测上的应用，已发表SCI论文50余篇，相关工作多次被Chemistry   - A European Journal、Analyst等国际高影响力杂志评选为研究亮点。相关成果已获得2014年北京市科学技术奖三等奖，中国分析测试协会科学技术奖（2009年一等奖、2012年一等奖、2014年二等奖）。已主持承担国家自然科学基金青年基金、教育部留学回国人员科研启动基金等科研项目，并参与中国科学院知识创新工程、“973”等项目。于2013年入选中国科学院青年创新促进会会员。在成果转化方面，已授权国家发明专利18项。

获奖情况

2017 年，四川大学大学生创新创业教育优秀指导教师

2014 年，北京市科学技术奖三等奖（排名第二）

2014 年，中国分析测试协会科学技术奖二等奖（排名第三）

2013 年，入选中国科学院青年创新促进会会员

2012 年，中国分析测试协会科学技术奖一等奖（排名第二）

2012 年，中国药学会科学技术奖三等奖（排名第四）

2009   – 2012 ，连续四年中国科学院化学研究所 “ 青年科学奖 ” 特别优秀奖

2010 年，中国科学院化学研究所 “ 优秀毕业生 ”

2010 年，中国科学院朱李月华优秀博士生奖

2009 年，中国分析测试协会科学技术奖一等奖（排名第四）

学生获奖情况

2019 年，四川大学优秀毕业研究生（杨春容）

2018 年，研究生国家奖学金（杨春容）

2018 年，四川大学优秀硕士（杨春容；黄丹）

2018 年，四川大学研究生科研创新基金（杨春容， 2018YJSY051 ）

2019 年，大学生创新创业训练计划（韩化怡，院级）

2018 年，大学生创新创业训练计划（苗家榕，校级；姚晔，校级）

2017 年，大学生创新创业训练计划（杜媛媛，省级；陈见驰，校级）

代表性成果 (获奖成果、专著、论文、专利)

 2019

1.Yang Chunrong; Yang Shu;   Song Lingbo; Yao Ye; Lin Xiao; Cai Kaicong; Yang Qianfan^*;   Tang Yalin, A resettable supramolecular platform for constructing scalable   Encoders, Chemical Communications, 2019, 55,   8005-8008

2. Huang Dan; Yang Chunrong; Yao Ye; Li Jicheng; Guo Chen; Chen   Jianchi; Zhang Yi; Yang Shu; Yang Qianfan^*; Tang   Yalin, Versatile and homogeneous DNA tetraplex platform for constructing   label-free logic devices: from design to application, Chemistry - A   European Journal, 2019, 25(28), 6996-7003

3.Yu Lijia; Yang   Qianfan^*; Tang Yalin^*, A comparative study of   assembly and disassembly process of dimeric and monomeric cyanine dyes with   DNA templates, Chinese Chemical Letters, 2019, 30(3): 694-697

4. Chen Jianchi^#; Yang Shu^#; Yang Chunrong;   Li Jicheng; Huang Dan; Lin Xiao; Guo Chen; Zhou Qiuju; Yang Qianfan^*;   Tang Yalin, A visible programmable supramolecular logic platform and its   application in intelligent thiols sensing, Chemistry - A European   Journal, 2019, 25, 5691-5697 (Inside   cover , Hot   paper )

5. Yang Shu; Yang Chunrong; Huang Dan; Song Lingbo; Chen Jianchi; Yang   Qianfan^*, Recent Progress in Fluorescence Signal Design   for DNA‐based Logic Circuits. Chemistry-A European Journal,   2019, 10.1002/chem.201804420   . (Invited minireview,   Frontispice)

2018

1. Yang Chunrong^#; Yang Shu^#; Li Jicheng; Du   Yuanyuan; Song Lingbo; Huang Dan; Chen Jianchi; Zhou Qiuju; Yang   Qianfan^*; Tang Yalin, Intelligent sensors of lead based on   a reconfigurable DNA-supramolecule logic platform. Analytical Chemistry,   2018, 90(17), 10585-10590   . (Supplementary cover)

2. Yang Chunrong; Song Lingbo; Chen Jianchi; Huang Dan; Deng   Junling; Du Yuanyuan; Yang Dehong; Yang Shu^*; Yang Qianfan^*;   Tang Yalin, A versatile DNA-supramolecule logic platform for multifunctional   information processing. NPG Asia Materials, 2018, 10, 497-508   .

3. Yang Chunrong; Zou Dan; Chen Jianchi; Zhang Linyan; Miao   Jiarong; Huang Dan; Du Yuanyuan; Yang Shu^*; Yang Qianfan^*;   Tang Yalin, A novel reconfigurable logic unit based on the DNA-templated   potassium-concentration-dependent supramolecular assembly. Chemistry-A   European Journal, 2018, 24, 4019-4025 . (Frontispice, Hot paper)

2017

1. Shen Gang; Zhang Hong^*; Yang Chunrong; Yang   Qianfan^*; Tang Yalin^*, Thrombin Ultrasensitive   Detection Based on Chiral Supramolecular Assembly Signal-Amplified Strategy   Induced by Thrombin-Binding Aptamer. Analytical Chemistry,   2017, 89 (1), 548–551.

2. Zhang Xiufeng^*; Lan Ling; Yang Shu; Rui Yulan; Li   Qian; Chen Hongbo; Sun Xin; Yang Qianfan^*; Tang   Yalin^*, Specific identification of human transferrin conformations   using a cyanine dye supramolecular assembly. RSC Advances, 2017,   44904–44907.

2011-2015

1. Yu Lijia; Yang Qianfan^*; Xiang Junfeng^*;   Sun Hongxia; Wang Lixia; Li Qian; Guan Aijiao; Tang Yalin^*,   Targeting of parallel c-myc G-quadruplex by dimeric cyanine dye   supramolecular assembly: dependence on the linker length. Analyst,   2015, 140(5), 1637-46.

2. Gai Wei; Yang Qianfan^*; Xiang Junfeng;   Jiang Wei; Li Qian; Sun Hongxia; Guan Aijiao; Shang Qian; Zhang Hong; Tang   Yalin^*, A dual-site simultaneous binding mode in the interaction   between parallel-stranded G-quadruplex [d(TGGGGT)]4 and cyanine dye 2,   2’-diethyl-9-methyl-selenacarbocyanine bromide. Nucleic Acids Research,   2013, 41 (4), 2709-2722.

3. Gai Wei^#; Yang Qianfan^#*;   Xiang Junfeng; Yu Lijia; Guan Aijiao; Li Qian; Sun Hongxia; Shang Qian; Jiang   Wei; Zhang Hong; Liu Yan; Wang Lixia; Tang Yalin^*, Novel   Dual-Functional Regulation of a Chair-Like Antiparallel G-quadruplex on   Inducing Assembly/Disassembly of Cyanine Dye. Physical Chemistry   Chemical Physics, 2013, 15, 5758-5761.

4. Gai Wei; Yang Qianfan^*; Xiang Junfeng;   Jiang Wei; Li Qian; Sun Hongxia; Yu Lijia; Shang Qian; Guan Aijiao; Zhang   Hong; Tang Yalin^*, A novel signal-amplified strategy based on   assembly reactivation for highly specific and sensitive detection of   chair-like antiparallel G-quadruplex. Analyst, 2013, 138 (3),   798-804. (Hot Article)

5. Gai Wei; Yang Qianfan^*; Xiang Junfeng;   Sun Hongxia; Shang Qian; Li Qian; Jiang Wei; Guan Aijiao; Zhang Hong; Tang   Yalin^*; Xu Guangzhi, Roles of flanking sequences in the binding   between unimolecular parallel-stranded G-quadruplexes and ligands. Chinese   Science Bulletin, 2013, 58, 731-740. (Cover   Article)

2005-2010

1. Yang Qianfan ;   Xiang JunFeng; Yang Shu; Li Qian; Zhou Qiuju; Guan Aijiao; Li Lin; Zhang   Yanxia; Zhang Xiufeng; Zhang Hong; Tang Yalin^*; Xu Guangzhi,   Verification of Intramolecular Hybrid/Parallel G-quadruplex Structure under   Physiological Condition by Using Novel Cyanine Dye H-aggregates: both in   Solution and on Au Film. Analytical Chemistry, 2010, 82 (22),   9135–9137.

2. Yang Qianfan ;   Xiang Junfeng; Yang Shu; Li Qian; Zhou Qiuju; Guan Aijiao; Zhang Xiufeng;   Zhang Hong; Tang Yalin^*; Xu Guangzhi, Verification of specific   G-quadruplex structure by using a novel cyanine dye supramolecular assembly:   II. The binding characterization with specific intramolecular G-quadruplex   and the recognizing mechanism. Nucleic Acids Research, 2010,   38, 1022-1033.

3. Yang Qianfan ;   Xiang Junfeng; Yang Shu; Zhou Qiuju; Li Qian; Tang Yalin^*; Xu   Guangzhi, Verification of specific G-quadruplex structure by using a novel   cyanine dye supramolecular assembly: I. Recognizing mixed G-quadruplex in   human telomeres. Chemical Communications, 2009, 1103-1105.

4. Yang Qianfan ; Xiang Junfeng; Li Qian; Yan Wenpeng; Zhou Qiuju; Tang Yalin^*;   Xu Guangzhi, Chiral Transformation of Cyanine Dye Aggregates Induced by Small   Peptides. Journal of Physical Chemistry B, 2008, 112,   8783-8787.